| English |
| autoimmune thrombocytopenic purpura |
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| Attestation |
3
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| Part of speech |
Noun syntagm
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| Grammatical label |
Uncountable
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| Variant |
ATP
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| Definition |
Autoimmune thrombocytopenic purpura is defined as isolated thrombocytopenia with normal bone marrow and the absence of other causes of thrombocytopenia. The 2 distinct clinical syndromes manifest as an acute condition in children and a chronic condition in adults. This disease is a decrease in the number of circulating platelets in the absence of toxic exposure or a disease associated with a low platelet count. Pathophysiology: ATP primarily is a disease of increased peripheral platelet destruction, with most patients having antibodies to specific platelet membrane glycoproteins. Relative marrow failure may contribute to this condition, since studies show that most patients have either normal or diminished platelet production. Acute ITP often follows an acute infection and has a spontaneous resolution within 2 months. Chronic ITP persists longer than 6 months without a specific cause.
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| Definition source |
E-Medicine - Instant Access to the Minds of Medicine.
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| Context |
Proof of an autoimmune pathogenesis requires adoptive transfer of disease by either immune cells or antibody. Transplacental or iatrogenic transfer of autoreactive antibodies may cause disease. This condition was first shown in Hanington´s self experimentation using plasma from a patient with autoimmune thrombocytopenic purpura.
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| Context source |
Richard K., et al. (2002). ‘Induction of tolerance in autoimmune diseases by hematopoietic stem cell transplantation: getting closer to a cure?’. Blood 99(3): 768-784. (RISCEN68)
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| Subject field |
Haemopoiesis
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| Sub-field (level 1) |
Thalassemias
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| Sub-field (level 2) |
Therapies
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| Coordinate concept |
Post-transfusional purpura, thrombotic thrombocytopenic purpura
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| it |
Porpora trombocitopenica autoimmune
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| Reliability code |
3
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