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| previous | mdr - collezione «Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta» - Federica Bordoni | next |
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Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
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| 3 |
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| multidrug resistance |
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| Simultaneous resistance to a broad spectrum of structurally and functionally distinct drugs following exposure to a single agent. It is thought to result from the overexpression of genes encoding an integral plasma membrane protein, p-glycoprotein. def2:The ability of bacteria and other microorganisms to withstand a drug to which they were once sensitive (and were once stalled or killed outright). A characteristic of cells that makes them resistant to the effects of several different classes of drugs. There are several forms of drug resistance.They each are determined by genes that govern how the cell will respond to the chemical agents. One type of multidrug resistance (or MDR) involves the ability to eject several drugs out of cells. The cell outer wall or membrane of the cell contains a pump that ejects chemicals, preventing them from reaching a toxic concentration. The resistance to drugs can be traced to the expression of genes that direct the formation of high amounts of the protein that prevents the drugs from having their effects on the malignant cells. If the gene or genes involved are not expressed or are weakly expressed, the cells are more sensitive to the drug´s effect. If the genes are highly expressed, the cells are less sensitive to the drug´s effect. Multi-drug resistance occurs when leukaemia cells eliminate anti-cancer drugs before a high enough concentration to kill the cells is achieved. Resistance against most drugs will make the leukaemia very difficult to treat. |
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| http://www.graylab.ac.uk/cgi-bin/omd?drug+resistance,+multiple http://www.leukemia.org/all_glossary.adp http://dspace.dial.pipex.com/lrf-/diseases/index.htm |
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| Multidrug resistance (MDR) describes the phenomenon of simultaneous resistance to unrelated drugs expressed by drug-resistant cells when compared to their drug-sensitive counterparts. |
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| http://courses.nus.edu.sg/course/patleesh/ish/1996/1996/027.pdf |
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| multiple drug resistance, drug-fast (?) |
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| Pediatric Oncohematology |
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| MDR |
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| MDR |
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| 3 |
