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| previous | karyotypic abnormalities - collezione «Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta» - Federica Bordoni | next |
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Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
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| 3 |
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| chromosomal abnormalities |
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| Abnormality in the number, form or structure of chromosomes. Particular abnormalities are associated with particular sub-types of leukemia. Loss of whole chromosomes or parts of chromosomes (deletions), extra chromosomes, switches of pieces of chromosomes from one to another (translocations) are examples of such abnormalities. A minus sign is used to indicate a deletion. For example, “-7” represents the loss of chromosome 7. This abnormality can also be referred to as monosomy 7. The chromosomes involved in a translocation are in brackets separated by a semicolon. The designation “t(8;21)” indicates that a translocation of a piece of chromosome 8 was exchanged for a piece of chromosome 21. |
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| http://www.leukemia-lymphoma.org/all_glossary.adp |
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| Within the TEL/AML1-positive group, the in vitro resistance profile was compared between the 7 patients with apparently normal karyotype versus the 22 patients with additional karyotypic abnormalities; there were no significant differences for any of the drugs tested. |
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| en03 |
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| Pediatric Oncohematology |
