a semisynthetic podophyllotoxin derivative C29H32O13 used to treat various neoplastic diseases (as carcinoma of the lungs or testicles, AIDS-related Kaposi´s sarcoma, acute leukemia, and Ewing´s sarcoma).
In the latter trial, patients with B-lineage ALL who received pharmacologically adapted doses of MTX, cytarabine , and etoposide had a 5-year EFS of 76%, whereas patients given standard medication had an EFS of 66%.