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| previous | allogeneic stem cell transplantation - collezione «Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta» - Federica Bordoni | next |
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Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
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| The transfer of stem cells from one person, the donor, to another, the recipient who is not an identical twin. In practice one makes an effort to find a donor who is very similar in tissue type to the recipient by matching their HLA types. The closer the similarity the higher the probability that the transplant will be a success and that harmful immune reactions will be minimized. Siblings are the most likely to be closely matched, but other family members and unrelated matched donors can be similar enough to achieve a successful transplant if the optimal match is not available and the severity of the illness justifies the risk. In the treatment of leukemia, lymphoma, and myeloma, the cells to be transplanted are pluripotential stem cells, but they are admixed with other marrow or blood cells when infused. |
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| http://www.leukemia-lymphoma.org/all_glossary.adp?item_id=9286 |
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| Patients between the ages of approximately 1 and 50 years who are in remission and have an HLA-matched donor are candidates for allogeneic stem cell transplantation. The decision to do a transplant depends on the features of the leukemia, the age of the patient, and the patient´s (or his or her family´s) understanding of the potential benefits and risks. The high rate of cure of children with acute lymphoblastic leukemia treated with chemotherapy decreases the frequency that stem cell transplantation is considered. A child with features that indicate a good prognosis would not be a candidate for transplantation unless their course was marked by a poor response to treatment or a relapse. |
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| en34 |
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| Pediatric Oncohematology |
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| PBSCT |
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| allogene SZT |
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| trapianto di cellule staminali da sangue periferico allogenico |
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