an alkaloid C46H56N4O10 that is obtained from a periwinkle (Catharanthus roseus synonym Vinca rosea) and that is used especially in the form of its sulfate to treat some human neoplastic diseases (as leukemias and Wilms´ tumor).
All patients received a 3drug reinduction phase;HD-L-ASP (E.Coli, Bayer) was given to HR patients; continuation therapy with6MP, i.m. MTX, monthly vincristine and prednisone pulses was given to all patients.