Medicina: Oncoematologia pediatrica: Leucemia linfoblastica acuta
| English |
| vindesine |
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| Attestation |
3
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| Definition |
Mitotic Inhibitor. Vindesine is a vinca alkaloid which is a synthetic derivative of vinblastine. Vindesine binds to the microtubular proteins of the mitotic spindle, leading to crystallization of the microtubule and mitotic arrest or cell death. The vinca alkaloids are considered to be cell cycle phase-specific.
Vindesine belongs to the group of medicines known as antineoplastic agents . It is used to treat some kinds of cancer, including leukemia and lung cancer. Vindesine interferes with the growth of cancer cells, which are eventually destroyed. Since the growth of normal body cells may also be affected by vindesine, other effects will also occur. Some of these may be serious and must be reported to your doctor. Other side effects , such as hair loss, may not be serious but may cause concern.
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| Definition source |
http://www.bccancer.bc.ca/pg_g_05.asp?PageID=1410&ParentID=4
http://www.nlm.nih.gov/medlineplus/druginfo/vindesinesystemic500129.html
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| Context |
In both protocols, induction therapy was followed by intensive consolidation consisting of nine 6-day cycles containing combinations of dexamethasone, vindesine/vincristine, 6-thioguanine/6-mercaptopurine, ifosfamide, etoposide, tripledrug intrathecal therapy, and high-dose therapy with either methotrexate or cytarabine.
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| Context source |
en16
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| Synonym |
Desacetylvinblastine amide, DAVA, DVA, VDS.
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| Subject field |
Pediatric Oncohematology
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| Generic concept |
antineoplastic drugs
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| de |
VDS
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| it |
VDS
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| Reliability code |
3
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| Note |
common trade name: Eldisine®
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